Spermidine is a longevity supplement that has rapidly gained popularity in the last few years. The reason why is easy to understand: studies show that this natural compound can help you live longer, postpone the onset of age-related health issues, and protect against cardiovascular disease and neurodegeneration on a cellular level (1).

At the same time, fasts like the 5:2 diet and the alternate-day fast have become popular for the same reasons. Fasting, like spermidine, is linked to improved cellular health and all kinds of potential health benefits. But can these two powerful tools be combined?

In this article, we’ll explore how spermidine supplementation can help boost the effects of caloric restriction on the body, and how to take spermidine while fasting safely and effectively. Read on to find out more.